Cell Bio Bite Topic:
Lessons from Biological Membranes, Liposomes for Drug Delivery
Advantages of Pectin Coating of Liposomes for Drug Delivery
Liposomes are miniscule vesicles composed of hydrophilic and hydrophobic ends used for many processes in the body including delivery of pharmaceuticals, more often known as medication. For the delivery of drugs that are hydrophilic and hydrophobic, the liposome is used (Alund et al., 2013). Prior to the drug delivery process, these liposomes are coated with a gel-like substance called pectin found to be very mucoadhesive. Pectin coating of liposomes is proven to be very advantageous to the drug delivery process in its ability to prolong drug release and shift characteristics of liposomes such as zeta potential and diameter size.
Pectin is most commonly used in jams and jellies as a gelling agent but can also be used for drug delivery because of its adhesive properties (Nguyen et al., 2011). The pectin coating on liposomes is demonstrative of increasing efficiency of drug delivery in the body. Pectin coating can increase the mucoadhesivity of the liposome to prevent the liposomes from decreasing in size therefore, prolonging drug release (Alund et al., 2013). The pectin coating’s ability to prolong drug release in the body is advantageous because with increased retention time, delivery of drugs can happen in a controlled, slow and efficient manner (Tiwari et al., 2012).
In addition to the adhesive properties of pectin coating of liposomes, the coating also has an effect on the components and measurements of liposomes. Zeta potential measures the potential difference between the layer the particles are dispersed from and their how far they are dispersed and is a indication of presence of pectin coating in liposomes, as well as the change in diameter of the liposomal particles. Following the application of pectin coating, the zeta potential in liposomes becomes more negative and larger in diameter...
References: Alund, S.J., Smistad, G., & Hiorth, M. (2013). A multivariate analysis investigating different factors important for the interaction between liposomes and pectin. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 420, 1-9. Retrieved October 18th, 2013, from Science Direct database.
Klemetsrud, T., Jonassen, H., Hiorth, M., Kjoniksen, A., Smistad, G. (2013). Studies on pectin-coated liposomes and their interaction with mucin. Colloids and Surfaces B: Biointerfaces, 103, 158-165. Retrieved October 18th, 2013, from Science Direct database.
Nguyen, S., Alund, S.J., Hiorth, M, Kjoniksen, A., Smistad, G. (2011). Studies on pectin coating of liposomes for drug delivery. Colloids and Surfaces B: Biointerfaces, 88, 664-673. Retrieved October 9th, 2013, from Elsevier database.
Tiwari, G., Tiwari, R., Sriwastawa, B., Bhati, L., Pandey, S., Pandey, P., et al. (2012). Drug delivery systems: an updated review. US National Library of Medicine National Institutes of Health, 2(1), 2-11. Retrieved October 19th, 2013, from The National Centre for Biotechnology Information database.
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