Ciprogen Drug

Topics: Renal failure, Adverse drug reaction, Pharmacology Pages: 15 (3245 words) Published: June 29, 2013
Ciprogen Drug Information
Ciprogen category:
Human
Antibacterials
Urinary Anti-Infectives
Active ingredients:
Ciprofloxacin
Ciprogen companies and manufacturers:
Merck
General Drugs House
Ciprogen forms, composition and dosages:
N / A
Indications, usages and classification codes:
J01MA02 - Ciprofloxacin

There is an additional general information about this medication active ingredient ciprofloxacin: Pharmacological action
Broad-spectrum antimicrobial drug of fluoroquinolone group with bactericidal action. Inhibits DNA gyrase and inhibits the synthesis of bacterial DNA. Highly active against most gram-negative bacteria: Pseudomonas aeruginosa, Haemophilus influenzae, Escherichia coli, Shigella spp., Salmonella spp., Neisseria meningitidis, Neisseria gonorrhoeae. It is active against Staphylococcus spp. (including strains producing and not producing penicillinase, methicillin-resistant strains), some strains of Enterococcus spp., Campylobacter spp., Legionella spp., Mycoplasma spp., Chlamydia spp., Mycobacterium spp. ciprofloxacin is active against bacteria producing beta-lactamases. Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides resistant to ciprofloxacin. The effect on Treponema pallidum is studied not enough. Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract. Bioavailability after oral administration of 70%. Eating has a little effect on the absorption of ciprofloxacin. Plasma protein binding is 20-40%. Distributed in tissues and body fluids. It penetrates the cerebrospinal fluid: the concentration of ciprofloxacin for not inflamed meninges reach 10% with inflammation - up to 37%. High concentrations are achieved in bile. Excreted in the urine and bile. Why is Ciprogen prescribed?

Infectious-inflammatory diseases caused by microorganisms susceptible to ciprofloxacin, including respiratory diseases, diseases of abdominal and pelvic organs, bones, joints, skin, septicemia; severe infections of ENT organs. Treatment of postoperative infections. Prevention and treatment of infections in patients with reduced immunity. For local use: acute and subacute conjunctivitis, blepharoconjunctivitis, blepharitis, bacterial corneal ulcers, keratitis, keratoconjunctivitis, chronic dacryocystitis, meybomity. Infectious lesions in the eyes from injury or contact with foreign bodies. Preoperative prophylaxis in ophthalmic surgery. Dosage and administration

Individual. For oral administration dose is 250-750 mg 2 times / day. Treatment duration is from 7-10 days to 4 weeks. For IV administration a single dose is 200-400 mg, the multiplicity of the introduction is 2 times / day, duration of treatment - 1-2 weeks and more if necessary. May be IV injected as jet but more preferably a drip for 30 minutes. When applied topically instilled 1-2 drops into the lower conjunctival sac of the affected eye every 1-4 hours. After improving the intervals between instillation can be increased. The maximum oral daily dose for adults is 1.5 g. Ciprogen side effects

Digestive system: nausea, vomiting, diarrhea, abdominal pain, increase in liver transaminases, alkaline phosphatase, LDH, bilirubin, pseudomembranous colitis. CNS: headache, dizziness, fatigue, insomnia, nightmares, hallucinations, fainting, disorders of vision. Urinary system: crystalluria, glomerulonephritis, dysuria, polyuria, albuminuria, hematuria, transient increase of serum creatinine. Hemopoietic system: eosinophilia, leukopenia, neutropenia, changes in the number of platelets. Cardiovascular system: tachycardia, cardiac arrhythmias, hypotension. Allergic reactions: itching, urticaria, Quincke's edema, Stevens-Johnson syndrome, arthralgia. Adverse reactions associated with the chemotherapeutic effect: candidiasis. Local reactions: pain, phlebitis (for IV injections). When applying eye drops in some cases may be mild pain and conjunctival hyperemia. Other: vasculitis.

Contraindications
Pregnancy, lactation...
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