Metabical Analysis Study Guide

Topics: Obesity, Prescription drug, Pharmacology Pages: 8 (2424 words) Published: August 14, 2011
Metabical Analysis
1)
Benefits:
* All other Weight-Loss Options in Exhibit 2 are more expensive that the target $30/ month out of pocket cost. * No other weight loss option offers cost containment cards. * No other product combines two mechanisms for weight loss:  Metabical combines two pharmacologic mechanisms to produce weight loss:     Fat blocker, meditonan and appetite suppressant, calosera. Due to the dual mechanism, the medications can be dosed in lower levels and therefore have a better safety profile and fewer side effects than either of the medications that have similar mechanisms, Meridia (prescription appetite suppressant phentermine) or Xenical (originally prescription fat blocker, now over the counter in a lower dose with fewer side effects, Alli) * Metabical is dosed once daily, which leads to better patient compliance than over the counter Alli, which must be taken with each meal in order to block fat absorption.  * Metabical is FDA approved, which demonstrates efficacy and relative safety as compared to over the counter or herbal remedies. * Metabical is dispensed by prescription only, which allows physicians to have more control and awareness of what their patients are taking, and to coordinate the use of Metabical with other prescription drugs in a group of patients (moderately obese), who are prone to obesity related disease states, such as heart disease, hypertension, diabetes, sleep apnea, and joint injuries. * Metabical is the only prescription weight loss medication with an indication for moderate obesity (BMI 28-30).  Other prescription weight loss preparations are indicated for morbidly obese patients with BMI < 30. * As a prescription drug, physicians are also able to combine Metabical with nutrition counseling or behavior modification support.  * As compared to structured weight loss options, such as Weight Watchers or Jenny Craig, Metabical offers the addition of appetite suppression and fat blocking in addition to nutrition counseling and group support. * As compared to over the counter options, such as xenadrine (now removed from shelves due to an increased risk of stroke, hypertension, and seizures), Metabical has been shown to be considerably safer. * As compared to over the counter Alli, Metabical is taken once a day, and has less incidence of oily diarrhea--a result of the inability to absorb fat, which remains in the digestive tract--since the fat blocker (calosera) has a relatively lower dose. * Metabical has been effective, compared to placebo, with average weight loss 15 lbs, vs. an average os 2 lbs for the control group. * As compared with multiple over the counter health food remedies, such as Trimspa, Cortislim, and Acai Berry, Metabical has demonstrated effectiveness in controlled clinical trials, and the non-FDA approved regimens have not demonstrated effectiveness. * As compared with exercise alone, such as a gym membership, Metabical increases weight loss by blocking fat and by decreasing appetite. Challenges:

* Metabical has side effects that exercise regimens and behavior modification do not have.  Despite lower dosing of calosera and meditonan, side effects do persist. * Metabical is more costly than many weight loss options, such as an independent exercise regimen. * The cost of Metabical is not generally covered by insurance. * As a prescription drug, Metabical is more inconvenient to obtain than over the counter medications, or medications that can be obtained on-line. * As a prescription drug, there are mandatory health warnings that may concern consumers. * The FDA does trend-watching and post marketing surveys, which may identify additional health risks, or failure to meet weight loss expectations that may cause removal from the market.  Fen-Phen is an example---in the early '90's, Fen-Phen caused dramatic weight loss, but in combination, these medications also caused unexpected and catastrophic heart...
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