pharm notes 1

Topics: Pharmacology, Adverse drug reaction, Hypertension Pages: 39 (7927 words) Published: November 15, 2014
Pre 2

The Food and Drug Administration
 
 
B.

Binding to plasma proteins can affect

distribution, metabolism and elimination

After a drug is administered, it goes to the site of action. Soon after this, the blood level of the drug begins to decline. This decline in blood levels best represents

3.
metabolism
 

An important advantage of administering a drug intravenously is that

the onset of action is faster than other routes.

Which pregnancy category indicates that there is evidence of human fetal risk but that use of the drug might still be acceptable if the woman is very ill and there are not safer, effective drug choices.

.
Category D

According to the Drug Enforcement Agency, which drug class has the highest potential for abuse? Schedule 1

When a drug is heavily plasma protein bound, the fraction of the drug that exerts the pharmacological effect is the

free drug

After a drug is administered, it goes to the site of action. Soon after this, the blood level of the drug begins to decline. This decline in blood levels best represents

Metabolism

If a rapid onset of action is important, which route of administration would you choose?

Intravenous

Which pregnancy category indicates that controlled studies in humans have not shown risk to the mother or fetus?

Category A

Post 2

One reason why most drugs have side effects is because

drugs bind to more than one receptor.

A drug company is conducting a "Phase III" study on a new drug. Which activity will be occuring?

The drug will be tested on patients who might benefit from it.

Which property of drugs is determined by the degree that a drug can be absorbed and transported by the body to its active site?

Bioavailability

Drug K can be administered by mouth or parenterally (by injection in vein or tissue). However, the drug dose needed to produce therapeutic blood levels is three times higher when the drug is administered by mouth. Which of the following provides the best explanation for this phenomenon?

first-pass liver metabolism of oral dose

Not all drugs in use today have been rated for safety in pregnancy. Of those that have been rated, which classification represents the greatest risk?

Category X

Drugs may not be sold in the United States until they have been approved by:

The Food and Drug Administration

When a drug is heavily plasma protein bound, the fraction of the drug that exerts the pharmacological effect is the

free drug

Which of the following is recommended by the FDA to reduce medication errors?

Use of bar codes on patient name bands.

Pharmacists are licensed to perform all of the following activities EXCEPT:

We should give a beta-blocker drug early on and at discharge for patients with heart attacks.

One reason why most drugs have side effects is because

drugs bind to more than one receptor.

A drug company is conducting a "Phase I Clinical Trial" study on a new drug. Which activity will be occuring?

The drug will be tested in a small number of healthy volunteers.

Which of the following affects drug absorption from the site of administration?

solubility.

S. Henry has been taking digoxin for many years. Knowing that digoxin is highly plasma protein bound, what do you predict will occur if you give him a second drug that also binds plasma proteins?

the potential for digoxin toxicity will increase
For the breastfed infant, factors which enhance drug excretion into breast milk include:

Maternal drug level is high

Drugs may not be sold in the United States until they have been approved by:

The Food and Drug Administration

Recently the FDA has reccommended the use of Tall man lettering, such as DOPamine rather than dopamine. The purpose of this is to

reduce drug name confusion that could cause errors.

A drug that occupies a receptor but does not activate the receptor is an:

antagonist.

Pharmacists are...
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