Randomized, Controlled Trial Comparing Synchronized Intermittent Mandatory Ventilation and Synchronized Intermittent Mandatory Ventilation Plus Pressure Support in Preterm Infants.

Topics: Mechanical ventilation, Pediatrics, Childbirth Pages: 2 (390 words) Published: June 26, 2013
Randomized, controlled trial comparing synchronized intermittent mandatory ventilation and synchronized intermittent mandatory ventilation plus pressure support in preterm infants.|  
Authors: Reyes ZC,Claure N,Tauscher MK,D'Ugard C,Vanbuskirk S,Bancalari E, Address: Division of Newborn Medicine, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL 33101, USA. Journal: Pediatrics.

Publication: 2006 Oct;118(4):1409-17.

abstract
BACKGROUND:
Prolonged mechanical ventilation is associated with lung injury in preterm infants. In these infants, weaning from synchronized intermittent mandatory ventilation may be delayed by their inability to cope with increased respiratory loads. The addition of pressure support to synchronized intermittent mandatory ventilation can offset these loads and may facilitate weaning. OBJECTIVE:

The purpose of this work was to compare synchronized intermittent mandatory ventilation and synchronized intermittent mandatory ventilation plus pressure support in weaning from mechanical ventilation and the duration of supplemental oxygen dependency in preterm infants with respiratory failure. METHODS:

Preterm infants weighing 500 to 1000 g at birth who required mechanical ventilation during the first postnatal week were randomly assigned to synchronized intermittent mandatory ventilation or synchronized intermittent mandatory ventilation plus pressure support. In both groups, weaning followed a set protocol during the first 28 days. Outcomes were assessed during the first 28 days and until discharge or death. RESULTS:

There were 107 infants enrolled (53 synchronized intermittent mandatory ventilation plus pressure support and 54 synchronized intermittent mandatory ventilation). Demographic and perinatal data, mortality, and morbidity did not differ between groups. During the first 28 days, infants in the synchronized intermittent mandatory ventilation plus pressure support group reached minimal...
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